6-OXO – Bodybuilding Supplement

6-OXO is a drug or nutritional supplement that may increase the testosterone-oestrogen ratio. 4-androstene-3,6,17-trione (4-AT) is an irreversible aromatase inhibitor, permanently binding and inactivating aromatase in adipose and peripheral tissue.[2] Aromatase is responsible for the conversion of testosterone to estradiol. Blocking the production of estradiol causes the body to upregulate the production of both aromatase and the substrate testosterone, restoring normal levels of estradiol but increasing serum testosterone levels. Since testosterone has anabolic activity and estradiol does not, elevated testosterone levels may increase anabolic muscle-building effects, although there have been no studies to confirm this.

4-AT is also used by steroid or prohormone users to counteract estrogen level increases caused by aromatization during their steroid cycle. This helps minimize side effects such gynecomastia but can lead to acne. Also, after a steroid cycle, the compound may be used to shorten the recovery from the testicular suppression that can be the result of the use of steroids.

A recent United States patent application claims an 88% increase in plasma testosterone levels in men, while decreasing oestrogen levels by 11%. The subjects took 300mg orally twice a day for four weeks without taking any other drugs or supplements. A typical dosage regimen is 200-600mg orally once a day in the evening, for a 4-6 week cycle.

There is still no conclusive evidence to support the effectiveness of this supplement.

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